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Synchronous transitional cell carcinoma and metastatic hepatocellular carcinoma in the urinary bladder: a case report

Al-Brahim Nabeel; Alowami Salem; Davis Ian; Daya Dean; Departments of Pathology and Molecular Medicine, McMaster University, Henderson

Dec 2004 (Vol. 11, Issue 6, Pages( 2463 - 2466)

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An 83- year-old male presented with intermittent hematuria and obstructive symptoms. A CT scan of the abdomen and pelvis showed diffuse thickening of the urinary bladder and a large 10 cm liver mass. Histopathological examination of bladder biopsy demonstrated two distinct lesions. The surface showed non-invasive urothelial carcinoma and the submucosa demonstrated metastatic hepatocellular carcinoma showing bile pigment and expressed Hep Par 1 and CD10. To the best of our knowledge, this is the first case report of synchronous transitional cell carcinoma and metastatic hepatocellular carcinoma of the urinary bladder.