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Germline testing for prostate cancer prognosis: implications for active surveillance
Program for Personalized Cancer Care and Division of Urology, NorthShore University HealthSystem, Evanston, Illinois, USA
Oct  2019 (Vol.  26, Issue  52, Pages( 48 - 49)
PMID: 31629432


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  • Based upon an evidence-based review of recently published manuscripts including our own studies, we first review germline variants that are significantly associated with prostate cancer aggressiveness and progression. We then discuss the clinical implication of germline variants in predicting grade reclassification of prostate cancer patients undergoing active surveillance. Finally, based on currently available evidence, we propose a working recommendation of germline testing and corresponding clinical management for localized prostate cancer patients, including those undergoing active surveillance.