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Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis
Temple University Hospital, Philadelphia, Pennsylvania, USA
Apr  2015 (Vol.  22, Issue  2, Pages( 7755 - 7757)
PMID: 25891343


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  • Cutaneous metastases from urologic cancers are very uncommon, usually represent widespread metastatic disease and are associated with a very poor prognosis. They may occur in 1% of patients with urologic malignancies, most commonly from kidney, followed by bladder and prostate tumors. In this report, we describe a case of urothelial carcinoma with metastases to the scrotum treated with platinum based chemotherapy with a durable complete response lasting more than 14 months. Molecular profiling revealed deleterious mutations in e-cadherin and retinoblastoma genes, suggesting their possible role in the pathogenesis of cutaneous metastases. Further studies are needed to validate this observation.