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Phenotype symptom severity and treatment in a cured cohort of chronic pelvic pain syndrome patients
Cleveland Clinic Glickman Urological and Kidney Institute, Cleveland, Ohio, USA
Feb  2015 (Vol.  22, Issue  1, Pages( 7623 - 7626)
PMID: 25694009


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    To identify a cohort of chronic pelvic pain syndrome (CPPS) patients who considered their symptoms completely resolved and analyze their demographics, clinical phenotype, treatments and NIH-Chronic Prostatitis Symptom Index (CPSI) scores.


    We identified 35 CPPS patients who at the follow up, reported their symptoms completely resolved ('cured'). Demographics, UPOINT phenotypes, treatments, and CPSI scores were examined. We also compared these variables to a database of 220 previously evaluated CPPS patients.


    Patients ranged in age from 19 to 72 years. Median follow up was 12 months. Mean change in CPSI sub scores before and after therapy were pain 9.7 +- 3.8 to 2.7 +- 2.9, urinary 4.0 +- 2.8 to 1.1 +- 1.2, QoL 8.1 +- 2.7 to 2.3 +- 2.5, and total 21.8 +- 6.6 to 6.2 +- 1.0 (all p < 0.0001). Only 9 (26%) patients reported a total score of 0. Comparing this 'cured' group to a previously published cohort of phenotyped CPPS patients, the 'cured' group had lower starting total and pain CPSI scores (21.8 versus 25.0 p = 0.007; 9.7 versus 11.5 p = 0.006 respectively).


    Many men with CPPS can reach a subjective cure, however, the majority do not reach a CPSI score of 0. This group of 'cured' patients is similar to our typical tertiary referral cohort in terms of age and phenotype but differs in having slightly lower pre-treatment CPSI scores.