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Prolonged natural progression from localized to symptomatic renal cell carcinoma
Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Dec  2012 (Vol.  19, Issue  6, Pages( 6578 - 6580)
PMID: 23228296


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  • Surgical excision is the gold standard therapy for clinically localized renal masses. Nevertheless, prognostication of the natural history of untreated renal cell carcinoma (RCC) remains a clinical challenge. While active surveillance (AS) has emerged as a viable treatment option in select patients with localized tumors and significant competing mortality risks, long term follow up data to assess the risk of disease progression are limited. We present a case of a localized, clinical stage T2 renal mass progressing to regional and systemic disease over 6 years, demonstrating that kinetics of disease progression may be prolonged and are yet to be fully understood.