Abstract

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• Many men with prostate cancer will have locally advanced disease, either at presentation or later in their clinical course. Alternative treatment options for this stage of disease include locoregional radiation therapy, or systemic treatment. This article will present a discussion of the use of radiation therapy for locally advanced disease focusing on three methods of improving effectiveness of treatment: increasing the relative integral dose; decreasing the volume of tumor present by neoadjuvant hormonal therapy and radiobiologic optimization.