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Receiver operating characteristic (ROC) curve analysis of transrectal ultrasonographic prostate cancer detection
Department of Urologic Surgery, University Hospital, University of Western Ontar
Mar 1997 (Vol. 4, Issue 1, Pages( 293 - 299)

Abstract

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  • PURPOSE: To provide an overview of receiver operating characteristics (ROC) curve theory and create an ROC curve describing transrectal ultrasound (TRUS) detection of prostate cancer (PCa). METHODS: One hundred thirty-two patients with either an abnormal digital rectal exam (DRE) or a prostate-specific antigen (PSA) above 4 ng/ml or both underwent TRUS and biopsy of the peripheral zone (PZ) of each quadrant. ROC software was used to create an ROC curve.

    RESULTS:

    One hundred seventy-nine of 528 quadrants (34%) harbored PCa. The performance of TRUS in detection of PCa as defined by the area below the ROC is 0,809.

    CONCLUSIONS:

    Future investigators are encouraged to employ ROC analysis of TRUS to permit more meaningful comparisons of performance.

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canadian journal of urology