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Does a prior cancer diagnosis impact PSA testing? Results from the National Health Interview Survey
Department of Urology, Chaim Sheba Medical Center, Ramat Gan, Israel, affiliated to The Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel
Jun  2023 (Vol.  30, Issue  3, Pages( 11551 - 11557)
PMID: 37344467


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  • Introduction:

    Prostate-specific antigen (PSA) testing remains a controversial issue. However, most urological guidelines recommend PSA testing in men aged 55-69 through a shared decision-making process with the patient. The impact of prior cancer diagnosis on PSA testing is not well-known. To compare PSA testing in men aged 55-69 years with and without a history of cancer (excluding prostate cancer patients).

    Materials and methods:

    Utilizing the National Health Interview Survey (NHIS), a retrospective cross-sectional study during the year 2018 was carried out. Multivariable logistic regression analysis was implemented to demonstrate potential associations with PSA testing and assess the association of cancer history.


    A total of 2,892 men aged 55-69 years from the NHIS survey who met the inclusion criteria were analyzed. A total of 308 (10.7%) men had a history of cancer (non-prostate). Men with a cancer history had a higher number of PSA tests and more recent testing than men with no previous cancer history. On multivariable analysis, men who were previously diagnosed with cancer had a higher likelihood of undergoing PSA testing compared to men with no history of cancer (OR: 1.87, 95% CI 1.39-2.52, p < 0.0001).


    Our data suggest that men aged 55-69 with a history of cancer are more likely to undergo PSA testing than men with no cancer history.