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Chronic lymphocytic leukemia/small lymphocytic lymphoma presenting as acute renal failure
Main Line Health, Bryn Mawr, Pennsylvania, USA
Feb  2022 (Vol.  29, Issue  1, Pages( 11036 - 11039)
PMID: 35150229


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  • Lymphoma of the urinary bladder is quite rare, accounting for a small percentage of all bladder neoplasms. Here we discuss the case of a 68-year-old male patient who initially presented with acute renal failure and severe bilateral hydronephrosis on ultrasound. Cross-sectional imaging further revealed a diffusely thickened bladder wall with extensive retroperitoneal and mesenteric lymphadenopathy. Bladder biopsies ultimately led to a diagnosis of stage IV chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). This is a rare instance of upper tract dilatation being the first sign of a widely disseminated hematologic malignancy.