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Solitary brain metastasis after recurrent adenocarcinoma of the prostate
Division of Urology, University of Colorado School of Medicine, Aurora, Colorado, USA
Feb  2021 (Vol.  28, Issue  1, Pages( 10565 - 10567)
PMID: 33625349


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  • Prostate cancer is rarely metastatic to visceral organs, and even less commonly to the brain. Recent data suggests brain metastasis from prostatic adenocarcinoma occur in 0.16% of patients, and almost universally in the setting of very high-volume disease. We present a man with an abruptly symptomatic brain lesion that developed at a PSA value of 1.5 ng/mL with no other known metastatic disease and required emergent neurosurgical resection. The patient had been initially treated with radiotherapy for Grade Group 4 prostate cancer in 2005 with a long period of PSA suppression.