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DNA repair genes: contributions to prostate cancer predisposition and aggressiveness
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
Oct  2019 (Vol.  26, Issue  52, Pages( 10 - 11)
PMID: 31629416


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  • Germline pathogenic mutations in DNA repair genes have been linked to prostate cancer risk and aggressiveness. This observation was facilitated by tumor sequencing of men with advanced prostate cancer and has important implications for clinical management. In addition, cascade testing will identify at-risk individuals who should be assessed for cancer risk.