Welcome to the CJU website » LOG IN


Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis
Temple University Hospital, Philadelphia, Pennsylvania, USA
Apr  2015 (Vol.  22, Issue  2, Pages( 7755 - 7757)
PMID: 25891343


Text-Size + 

  • Cutaneous metastases from urologic cancers are very uncommon, usually represent widespread metastatic disease and are associated with a very poor prognosis. They may occur in 1% of patients with urologic malignancies, most commonly from kidney, followed by bladder and prostate tumors. In this report, we describe a case of urothelial carcinoma with metastases to the scrotum treated with platinum based chemotherapy with a durable complete response lasting more than 14 months. Molecular profiling revealed deleterious mutations in e-cadherin and retinoblastoma genes, suggesting their possible role in the pathogenesis of cutaneous metastases. Further studies are needed to validate this observation.

Current Issue

December 2021, Vol.28 No.6
canadian journal of urology