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Transitional cell carcinoma of the bladder producing Parathyroid hormone-related protein (PTHrP)
Department of Medicine, Division of Hematology/Oncology, Medical University of S
Feb  2004 (Vol.  11, Issue  1, Pages( 2136 - 2138)


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  • Hypercalcemia associated with transitional cell carcinoma (TCC) is rarely encountered. We report a case of TCC of bladder with documented production of parathyroid hormone related protein (PTHrP). Our patient had a rapidly progressive course and died 2 months after radical cystectomy. Literature suggests that these patients present with advanced stage and carry a poor prognosis. The histopathologic features, treatment and prognosis associated with this rare paraneoplastic syndrome are reviewed.