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© The Canadian Journal of Urology™; 23(Supplement 1); February 2016
TABLE 2.
Potential drug-drug interactions of abiraterone and enzalutamide with other commonly used drugs
18
Rank Brand name Generic name Abiraterone Abiraterone Enzalutamine Enzalutamine
2010
interactions comments
interactions comments
1/ Lipitor/
Atorvastatin No significant
Avoid/use Avoid combo or monitor
11 apo-
interactions
alternative closely: combo may
atorvastatin
decr. statin levels, efficacy
(hepatic metab. induced)
5 Teva-
Amoxicillin No significant
Caution
Combo may incr. risk
amoxicillin
interactions
advised
of seizures (additive effects)
6 Nexium Esomeprazole No significant
Avoid/use Combo may decr.
interactions
alternative esomeprazole levels, efficacy
(hepatic metab. induced)
7 Teva-
Venlafaxine
No significant
Caution
Combo may incr. risk
venlafaxine XR
interactions
advised
of seizures (additive effects)
23 Adalat XL Nifedipine
No significant
Monitor/ Monitor BP: combo may
interactions
modify
decr. calcium channel
therapy
blocker levels, efficacy
(hepatic metab. induced)
26 Ratio-oxycocet Oxycodone No significant
Avoid/use Avoid combo or consider
(acetaminophen) interactions
alternative oxycodone dose adjustment:
combo may decr. oxycodone
levels, efficacy (hepatic
metab. induced)
27 Tylenol with Codeine
Caution Combo may No significant
codeine #3 (acetaminophen) advised decr. codeine interactions
efficacy (hepatic
conversion to
morphine decr.)
33/ Taro-warfarin/ Warfarin
No significant
Avoid/use Avoid combo or monitor
44 coumadin
interactions
alternative INR: combo may decr.
warfarin levels, efficacy
(hepatic metab. induced)
36/ Teva-
Metoprolol
Caution Combo may No signifcant
48 metoprolol/
advised incr. metoprolol interactions
apo-metoprolol
levels, risk of
adverse effects
(hepatic metab.
inhibited)
39 Flomax CR Tamsulosin Caution Combo may No significant
advised incr. tamsulosin interactions
levels, risk of
adverse effects
(hepatic metab.
inhibited)
41 Apo-
Prednisone
No significant
Caution
Combo may decr.
prednisone
interactions
advised
corticosteroid levels,
efficacy (hepatic metab.
induced)
Mak AND Barkin
34