Abstracts from the New England Section of the AUA 2021

© The Canadian Journal of Urology TM : International Supplement, October 2021 P7 Patient Reported Outcome Measures following Hyperbaric Oxygen Therapy for Radiation Cystitis: A Multicenter Registry for Hyperbaric Oxygen Therapy Consortium Rachel Moses, MD 1 , Eileen Brandes, MD 1 , Kevin Krughoff, MD 1 , Devin Cowan, BS 2 , Nicole Harlan, MD 1 , Judy Rees, PhD,MPH 3 , William Bihrle, III, MD 1 , Jay Buckey, Jr., MD 3 1 Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA; 2 Dartmouth College, Hanover, NH, USA; 3 Dartmouth Geisel School of Medicine, Hanover, NH, USA Introduction : Prior studies evaluating hyperbaric oxygen therapy (HBOT) have demonstrated reduced bladder bleeding interventions, however, few U.S. studies have evaluated HBOT’s association with patient reported outcome measures (PROMs). The purpose of this study is to evaluate the feasibility of collecting PROMs of patient reported hematuria events and bladder symptoms before and after HBOT through a multi-institutional registry. Materials & Methods : Prospectively collected data from 16 sites in the Multicenter Registry for Hyperbaric Oxygen Therapy Consortium were analyzed. Measures included a hematuria scale adapted from the RTOG/ EROCT radiation scale for cystitis, Urinary Distress Inventory (UDI) and a question on hematuria severity and quantity. Data obtained on the first and last days of HBOTwere compared usingWilcoxon rank sum test. Proportions were compared using chi-square tests. Results : 52 patients had complete RTOG/EROTC hematuria data, 26 had UDI data and 32 had both. Patients were on average 73 (+/- 17) years old, 16/52 were diabetic, 27/52 are current or former smokers and 39/52 developed radiation cystitis due to prostate cancer related radiation treatment. Referral for HBOT occurred approximately 6.5 +/-5.3yrs following radiation. All patients had >30 treatments. RTOG/EROTC hematuria scores were significantly improved post HBOT (2.3 pre vs. 1.1 post, p=0.0001), as was self-reported hematuria (p=0.02) ( Figure 1A ); UDI scores improved, but the difference was not statistically significant (33.9+/-28.3 vs. 27.9+/-23.0, p=0.53) ( Figure 1B ). Those with UDI scores above the median pre-HBOT, did show significant reduction post (p=0.004). Conclusions : In a novel, multi-institutional prospective data set, we demonstrate the feasibility of collecting PROMs in patients undergoing HBOT. HBOT reduced patient reported hematuria events significantly, but did not consistently reduce UDI scores in the small sample of patients with complete UDI data. Continued expansion of the registry may provide more generalizable results and allow for analysis of factors leading to improved or worsening UDI scores. Concurrent Poster Session I WITHDRAWN P6 Association Between Age at the Time of Surgery and Recovery of Urinary Continence in Men Undergoing Radical Prostatectomy Ghazal Khajir, MD , Jack Gagne, MD, Kamyar Ghabili, MD, Olamide Olawoyin, BS, Nathan Paulson, MD, Preston Sprenkle, MD Yale School of Medicine, New Haven, CT, USA Introduction: Urinary incontinence is one of the most concerning complications of radical prostatectomy (RP). Therefore, studies have focused on predicting different preoperative factors such as age at the time of surgery. Older patients seem to be at relatively higher risk of urinary incontinence after RP. However, there is still a debate over the specific cutoff for age associated with increased postoperative urinary incontinence rate. We sought to assess the association between different pre- and intraoperative factors, including age at the time of surgery and recovery of urinary continence (UC) in men undergoing RP. Materials & Methods: Between April 2013 and September 2020, men undergoing robotic-assisted laparoscopic prostatectomy (RALP) by a single urologist for clinically localized or locally advanced prostate cancer in our institution were studied. Age at the time of surgery, body mass index (BMI), type of surgical approach (nerve-sparing, Retzius-sparing), MRI-based prostate volume, preoperative PSA, serum testosterone level, and pathological T stage as well as Gleason grade group were documented. Achievement of UCwas defined as wearing no pads or an occasional security pad by patient- reported daily pad usage within 3 (early) and 12 months (late) after RALP. Results: One hundred seventy-eight patients underwent RALP. The median age of patients was 63 years old (interquartile range 58-67). Postoperatively, 65 (36.5%) and 133 (74.7%) men achieved early (3 months) and late (12 months) recovery of UC, respectively. Multivariate logistic regression revealed that younger age (OR 1.16; 95%CI 1.05-1.29; p=0.006) with lower BMI (OR 1.23; 95%CI 1.03-1.47; p=0.02) who underwent Retzius-sparing surgery (OR 5.12; 95%CI 1.37-19.05; p=0.01) showed early recovery of UC. Among different age categories, age of 60 years or younger was significantly associated with the achievement of early UC (OR 4.54; 95%CI 1.35-14.28; p=0.01). Conclusions: Early recovery of UC is primarily associatedwith patient-driven characteristics such as age and BMI. Age ≤60 years was associated with the achievement of early UC. P5 38